as noted by M fan(s), M has effectively contained Reed, Nailor and Dotson (and Toure), so they should be fine against OSU.
Olave, Wilson and Smith-Njigba are to the OSU team as Waddle and Devonte Smith were to Alabama last season. They are all game changers that can win games in a flash. In 2021, OSU has a QB in Stroud that's operating behind an NFL level OL and throwing to the best WR group in CFB with an OC in CRD calling the plays. This is miles different than M throttling MSU's and PSU's passing game. Neither of those two teams have the QBs or the OL to protect them from M's wrecking crew of Ojabo and Hutchinson and nether of them have the play calling acumen of Ryan Day calling plays on the sideline. James Franklin was particularly exploited by M's upstart new DC. That helped in that game.
So, it's really hard for me (or Linesman among others here) to listen to you wallow in self-pity over the misfortunes the OSU football team is going to experience in Ann Arbor. Do I think there is no chance for M to beat OSU? No. around a 49.5 or something close to that chance. I suspect Hannibal will come up with a 100% accurate prediction that M will lose. They could.
This M team, on eyeball check, is probably the best Harbaugh has had that will face OSU behind the coaching of CRD. All the fancy stats give M a slight theoretical advantage (expected because its a home game for M). Everyone, including myself and the fancy stats gave M a projected win over MSU and not by just a little. Instead M lost. I've attributed a large portion of the cause of that loss to variance. Some will disagree. Fine. Who will prevail in Ann Arbor in 11d is very hard to predict. If variance can be reduced, if it is a competently refereed game, M could win but that's asking a whole lot.
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